A question from laziedazie: In Cystic Fibrosis a change in a single gene causes the protein called CFTR to??
a. become less soluble
b. fold improperly
c. transport sodium ions instead of chloride ions
Chosen answer:
Answer by ewtaylor2001
b.
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Question by Ina: What mutation causes Cystic Fibrosis?
Can you also explain where on the chromosome the mutated gene is found?
How the mutation causes physical symptoms?
If the gene is recessive, do both alleles have to be recessive or do both alleles have to be heterozygous and have a 3:1 chance or homozygous and 4:0 chance.
My chosen answer:
Answer by ehsmom2006
Go to this website all of your answers will hopefully be there
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A question from C. Wright =P: in cystic fibrosis a change in a single gene causes the protien called CFTR to?
a. become less soluble
b. fold improperly
c. destroy the cell membrane
d. transport the sodium ions instead of chloride ions
Selected answer:
Answer by Tom H
C
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A question from Drink deeply and dream: What causes differences in the severity of Cystic Fibrosis?
I have identical twin girls (they’re 16) who have Cystic Fibrosis, they have always been in the same environment, but they seem to have two different severity levels of Cystic Fibrosis, one of my twins is sick very often and has had to spend numerous amounts of time in hospital, has much lower lung function, needs a feeding tube, and will need a lung transplant eventually, my other daughter does not get sick and get infections that much and has always been a lot stronger. What actually causes the differences since they are identical twins?
Selected answer:
Answer by Dixie
that’s the $ 64,000 question. This is a good question and it’s one we really don’t know the answer to yet.
It does give an example of how your genotype doesn’t always predict your phenotype.
My CF patients tell me frequently that they have the worst mutation, but their lung function is excellent and they are as healthy as I am.
One theory is that there are modifier genes that we just don’t know much about at this point, or how to turn them on or off. If we knew how to do that, we would have a cure for cancer too. It is perhaps why one twin has more symptoms than the other.
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A question from Pree Kay: What is the mechanism whereby the faulty Cystic Fibrosis gene causes production of thick mucus?
I have to draw a flow chart illustrating this. I looked on google for a long time but could not find much information. (It’s for Biology 12)
Most detailed answer:
Answer by Edric Z
As I understand it, it is primarily caused by an over absorption of liquid in the lungs into the lungs tissues. Not sure if the high sodium / low chloride content contributes to the viscosity or not. Pulmonary therapies add moisture and medications into the lungs to help liquefy the mucus so it can be expelled. This helps clean the lungs of foreign material as well as the buildup of mucus. Vigorous shaking/vibrating or percussion’s to the lungs also help the mucus to liquefy for expulsion.
Regards
EZ
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Question posed by 24 Character Nickname 
: How is the DNA sequence of the allele that causes cystic fibrosis different from that of the normal allele?
Chosen answer:
Answer by einas16
Cystic fibrosis happens when you have 2 reccessive alleles of a (mutated CFTR dysfunctional gene). the normal person has genes that can translate into a fully functional CFTR protein.. in cystic fibrosis patients they unfortunately inherit 2 recessive genes that (when transcribed into rna and translated into protein) fold differently and cause the protein to function less.
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